Publications

2024

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Vallmajo-Martin Q, Ma Z, Srinivasan S, Murali D, Dravis C, Mukund K, Subramaniam S, Wahl GM, Lytle NK. (2024) The molecular chronology of mammary epithelial cell fate switching. BioRXiv. doi:https://doi.org/10.1101/2024.10.08.617155.

 

2023

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Rahbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schurch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, Wen KW, Tsai S, Goggins MG, Lowy AM, Wechsler-Reya RJ, Von Hoff DD, Newman AM, Reya T. (2023) Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell. S1535-6108(23)00324-0.

 

Ferguson LP, Gatchalian J, McDermott M, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal S, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galvan J, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy A, Schurch C, Puri PL, Bruneau B, Hargreaves D, Reya T. (2023) Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nature Communications. 14(1):292.

 

2022

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Ma Z*, Lytle NK* (co-first author), Ramos C, Naeem RF, Wahl GM. (2022) Single-cell transcriptomic and epigenetic analyses of mouse mammary development starting with the embryo. Methods Mol Biol. 2471:49-82.

 

Gubbala VB, Jytosana N, Trinh VQ, Maurer HC, Naeem RF, Lytle NK, Ma Z, Zhao S, Lin W, Han H, Shi Y, Hunter T, Singh PK, Olive KP, Tan MCB, Kaech SM, Wahl GM, DelGiorno KE. (2022) Eicosanoids in the pancreatic tumor microenvironment – a multicellular, multifaceted progression. Gastro Hep Advances. 1(4):682-697.

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2021

 

Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Aroojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE. (2021) Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury. Gastroenterology. S0016-5085(21)03665-9.

 

2020

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Spinler K, Bajaj J, Ito T, Zimdahl B, Hamilton M, Ahmadi A, Koechlein CS, Lytle N, Kwon HY, Anower-E-Khuda F, Sun H, Blevins A, Weeks J, Kritzik M, Karlseder J, Ginsberg MH, Park PW, Esko JD, Reya T. (2020) A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. Nature Communications. 11(1):5998.

 

DelGiorno KE, Chung C-Y, Vavinskaya V, Maurer CH, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O’Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. (2020) Tuft cells inhibit pancreatic tumorigenesis in mice by producing prostaglandin D2. Gastroenterology. S0016-5085(20)34999-4.

 

Li Y-C, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. (2020) Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane targeted RAS binders. Proc Natl Acad Sci USA. 117(22):12121-12130.

 

Lusardi TA, Lytle NK, Gebril HM, Boison D. (2020) Effects of preinjury and postinjury exposure to caffeine in a rat model of traumatic brain injury. J Caffeine Adenosine Res. 10(1):12-24.

 

Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. (2020) Nup93 regulates breast tumor growth by modulating proliferation and actin cytoskeleton remodeling. Life Science Alliance. 3(1):e201900623.

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2019

 

Lytle NK*, Ferguson LP*, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schurch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galvan JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis N, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AL, Lowy AM, Adams P, Reya T. (2019) A multiscale map of the stem cell state in pancreatic cancer. Cell. 177(3):572-586. *contributed equally

 

Shi Y, Gao W*, Lytle NK*, Huang P, Dann AM, Ridinger M, DelGiorno KE, Erikson G, Sun H, Meisenhelder J, Terenziani E, Santisakultarm P, Manor U, Leblanc M, Umetsu SE, Collisson EA, Lowy AM, Reya T, Donahue TR, Downes M, Wahl GM, Evans RM, Pawson T, Tian R, Hunter T. (2019) Targeting LIF-mediated paracrine communication for pancreatic cancer therapy. Nature. 569(7754):131-135. *contributed equally

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2018

 

Lytle NK, Barber A, Reya T. (2018) Stem cell fate in cancer growth, progression and therapy resistance. Nature Reviews Cancer. 18(11):669-680.

 

Dravis C*, Chung C-Y*, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. (2018) Epigenetic and transcriptomic profiling of mammary gland development and tumor models disclose regulators of cell state plasticity. Cancer Cell. 34(3):466-482. *contributed equally

 

2017

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Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fragman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. (2017) Stress-activated NRF2-MDM2 cascade controls neoplastic progression in pancreas. Cancer Cell. 32(6):824-839.

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2016

 

Bajaj J*, Konuma T*, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T. (2016) CD98-mediated adhesive signaling enables the establishment and propagation of acute myelogenous leukemia. Cancer Cell. 30(5):792-805. *contributed equally

 

Fox RG*, Lytle NK* (co-first author), Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CK, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. (2016) Image based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 534(7607):407-11. *contributed equally

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2015

 

Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. (2015) Tetraspanin 3 is required for the development and propagation of acute myeloid leukemia. Cell Stem Cell. 17(2):152-164.

 

Shen HY, van Vliet EA, Bright KA, Hanthorn M, Lytle NK, Gorter J, Aronica E, Boison D. (2015) Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 99:554-565.

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2014

 

Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. (2014) Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U.S.A. 111(38):13870-13875.

 

Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, and Shao J. (2014) Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 9(5):e96432.

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2013

 

Williams-Karnesky RL, Sandau US, Lusardi TA, Lytle NK, Farrell JM, Pritchard EM, Kaplan DL, and Boison D. (2013) Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Invest. 123(8):3552-3563.

 

Duncan JE, Lytle NK, Zuniga A, and Goldstein LSB. (2013) The microtubule regulatory protein Stathmin is required to maintain the integrity of axonal transport in Drosophila. PLoS ONE. 8(6):e68324.

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2012

 

Shen HY, Singer P, Lytle N, Wei CJ, Lan JQ, Williams-Karnesky RL, Chen JF, Yee BK, and Boison D. (2012) Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia. J Clin Invest. 122(7):2567-2577.

 

Lusardi TA, Lytle NK, Szybala C, Li T, and Boison D. (2012) Caffeine prevents acute mortality after TBI in rats without increased morbidity. Exp Neurol. 234(1):161-168.

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2011

 

Li T, Lytle N, Lan J, Sandau US, and Boison D. (2011) Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis? Glia. 60(1):83-9