Project 1

Approximately 1/3 of all pancreatic cancer patients who undergo resection of their primary tumor will recur with metastasis in less than one year following surgery. Although standard-of-care chemotherapy aids in tumor control and can be highly effective in some patients, our studies demonstrate that chemotherapy damage to the liver may incidentally generate a pro-metastatic liver microenvironment that supports the survival and outgrowth of liver-resident disseminated tumor cells.